Journal article
Investigation of P. vivax elimination via mass drug administration: A simulation study
Md Nurul Anwar, James M McCaw, Alexander E Zarebski, Roslyn I Hickson, Jennifer A Flegg
Epidemics | Elsevier | Published : 2024
Abstract
Plasmodium vivax is the most geographically widespread malaria parasite. P. vivax has the ability to remain dormant (as a hypnozoite) in the human liver and subsequently reactivate, which makes control efforts more difficult. Given the majority of P. vivax infections are due to hypnozoite reactivation, targeting the hypnozoite reservoir with a radical cure is crucial for achieving P. vivax elimination. Stochastic effects can strongly influence dynamics when disease prevalence is low or when the population size is small. Hence, it is important to account for this when modelling malaria elimination. We use a stochastic multiscale model of P. vivax transmission to study the impacts of multiple ..
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Awarded by University of Melbourne
Funding Acknowledgements
This research was supported by The University of Melbourne's Research Computing Services and the Petascale Campus Initiative, Australia. J.A. Flegg's research is supported by the Australian Research Council, Australia (DP200100747, FT210100034) and the National Health and Medical Research Council, Australia (APP2019093). J.M. McCaw's research is supported by the Australian Research Council, Australia (DP210101920) and the NHMRC Australian Centre of Research Excellence in Malaria Elimination (ACREME) (APP1134989). The contents of the published material are solely the responsibility of the individual authors and do not reflect the views of NHMRC.